Therapy Detail

Therapy Name GDC-0349
Therapy Description

GDC-0349 is a selective ATP-competitive inhibitor of mTOR kinase activity, which may lead to growth inhibition of tumor cells (PMID: 23473235, PMID: 26759240).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GDC-0349 mTOR Inhibitor 48 GDC-0349 is a selective ATP-competitive inhibitor of mTOR kinase activity, which may lead to growth inhibition of tumor cells (PMID: 23473235, PMID: 26759240).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown breast cancer not applicable GDC-0349 Preclinical - Cell line xenograft Actionable In a preclinical study, the mTOR inhibitor GDC-0349 inhibited tumor growth in cell line xenograft models of solid tumors, including breast cancer (PMID: 24900569). 24900569
Unknown unknown prostate cancer not applicable GDC-0349 Preclinical - Cell line xenograft Actionable In a preclinical study, the mTOR inhibitor GDC-0349 demonstrated inhibition of tumor growth in cell line xenograft models of solid tumors, including prostate cancer (PMID: 24900569). 24900569
Unknown unknown Advanced Solid Tumor not applicable GDC-0349 Preclinical - Cell line xenograft Actionable In a preclinical study, the mTOR inhibitor GDC-0349 demonstrated inhibition of tumor growth in cell line xenograft models of solid tumors (PMID: 24900569). 24900569
Unknown unknown renal cell carcinoma not applicable GDC-0349 Preclinical - Cell line xenograft Actionable In a preclinical study, the mTOR inhibitor GDC-0349 demonstrated inhibition of tumor growth in cell line xenograft models of solid tumors, including renal adenocarcinoma (PMID: 24900569). 24900569
Clinical Trial Phase Therapies Title Recruitment Status