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|Therapy Name||Bintrafusp alfa + M6223|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Bintrafusp alfa||MSB0011359C|M7824||Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 112 TGFBR2 Antibody 3||Bintrafusp alfa is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).|
|M6223||M-6223|M 6223||M6223 targets and binds to TIGIT on immune cells, including tumor-infiltrating lymphocytes, and prevents its interaction with CD112 and CD155, thereby leading to enhanced interaction of CD112 and CD155 with CD226 expressed on natural killer and CD8 T+ cells, which may lead to the activation of anti-tumor immune responses (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04457778||Phase I||M6223 Bintrafusp alfa + M6223||First in Human Study of M6223 in Participants With Metastatic or Locally Advanced Solid Unresectable Tumors||Active, not recruiting||USA | CAN||0|