Therapy Detail

Therapy Name PR610
Synonym
Therapy Description

PR610 is a prodrug that is converted to a pan-HER inhibitor in hypoxic tumor conditions, thus inhibiting cellular proliferation and differentiation of tumor cells overexpressing HER kinases and potentially sparing healthy normal tissue (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PR610 EGFR Inhibitor (Pan) 42 HER2 Inhibitor 21 PR610 is a prodrug that is converted to a pan-HER inhibitor in hypoxic tumor conditions, thus inhibiting cellular proliferation and differentiation of tumor cells overexpressing HER kinases and potentially sparing healthy normal tissue (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable PR610 Preclinical Actionable In a preclinical study, PR610 inhibited EGFR auto-phosphorylation and downstream signaling, and induced cell-cycle arrest and an anti-proliferative response in human cancer cell lines in culture (Mol Cancer Ther 2013;12(11 Suppl):B278). detail...
Clinical Trial Phase Therapies Title Recruitment Status