Therapy Detail

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Therapy Name Riluzole
Synonyms
Therapy Description

Rilutek (riluzole) inhibits metabotropic glutamate receptors, which results in decreased signaling through the MAPK pathway and the PI3K/AKT pathway (PMID: 19458050), and also inhibits voltage-gated ion channels and may directly inhibit protein kinase C (PMID: 10964608).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Riluzole Rilutek PKC Inhibitor (Pan) 10 Rilutek (riluzole) inhibits metabotropic glutamate receptors, which results in decreased signaling through the MAPK pathway and the PI3K/AKT pathway (PMID: 19458050), and also inhibits voltage-gated ion channels and may directly inhibit protein kinase C (PMID: 10964608, PMID: 32304618).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown hepatocellular carcinoma not applicable Riluzole Preclinical - Cell culture Actionable In a preclinical study, Rilutek (riluzole) inhibited growth of hepatocellular cancer cell lines and primary hepatocellular cancer lines in culture (PMID: 27612558). 27612558

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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