Therapy Detail

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Therapy Name Olaparib + THZ1
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Olaparib Lynparza AZD2281|KU-0059436 PARP Inhibitor (Pan) 20 Lynparza (olaparib) binds to and inhibits PARP, resulting in inhibition of DNA repair and lethality in homologous-recombination deficient cells, and may be a sensitizing agent for chemotherapy and radiotherapy (PMID: 25028150, PMID: 24225019). Lynparza (olaparib) is FDA approved for treatment of ERBB2 (HER2)-negative breast cancer with deleterious or suspected deleterious germline BRCA mutations, ovarian cancer with deleterious or suspected deleterious germline BRCA mutations and received 3 or more prior therapies, metastatic pancreatic adenocarcinoma with deleterious or suspected deleterious germline BRCA mutations as a maintenance therapy, metastatic castration-resistant prostate cancer with deleterious or suspected deleterious germline or somatic homologous recombination repair gene mutations who progressed following enzalutamide or abiraterone, as a maintenance therapy in recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer and in epithelial ovarian, fallopian tube or primary peritoneal cancer with deleterious or suspected deleterious germline or somatic BRCA mutation, and in combination with Avastin (bevacizumab) as maintenance therapy in HDR defective epithelial ovarian, fallopian tube or primary peritoneal cancer as defined by deleterious or suspected deleterious BRCA mutation, and/or genomic instability (FDA.gov).
THZ1 HY-80013|THZ-1 CDK7 Inhibitor 13 THZ1 is a covalent Cdk7 inhibitor that inhibits tumor cell proliferation (PMID: 25043025, PMID: 32690037).

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable Olaparib + THZ1 Preclinical - Cell culture Actionable In a preclinical study, treatment with Lynparza (olaparib) combined with THZ1 resulted in a synergistic effect in homologous recombination-proficient prostate cancer cells, demonstrating decreased cell survival and reduced anchorage-independent growth in culture (PMID: 32668240). 32668240
Unknown unknown ovarian cancer not applicable Olaparib + THZ1 Preclinical - Cell culture Actionable In a preclinical study, treatment with Lynparza (olaparib) combined with THZ1 resulted in a synergistic effect in homologous recombination-proficient ovarian cancer cells, demonstrating decreased cell survival and reduced anchorage-independent growth in culture, and inhibition of tumor growth in cell line xenograft models (PMID: 32668240). 32668240
Unknown unknown triple-receptor negative breast cancer not applicable Olaparib + THZ1 Preclinical - Cell line xenograft Actionable In a preclinical study, Lynparza (olaparib) treatment combined with THZ1 resulted in a synergistic effect in homologous recombination-proficient triple-receptor negative breast cancer cells, demonstrating decreased cell survival and anchorage-independent growth in culture, and inhibition of tumor growth in cell line xenograft models (PMID: 32668240). 32668240

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Clinical Trial Phase Therapies Title Recruitment Status


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