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|Therapy Name||Azacitidine + Dubermatinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Azacitidine||Vidaza||azacytidine|CC-486|5-azacytidine|5-AC|U-18496|Onureg||DNMT inhibitor (Pan) 5||Vidaza (azacitidine) is a cytidine analog that incorporates into DNA and RNA and binds to DNA methyltransferases (DNMTs), resulting in DNMT degradation and decreased DNA methylation, and leading to increased tumor cell death (PMID: 28159832, PMID: 28067760). Vidaza (azacitidine) is FDA-approved for use in patients with some subtypes of myelodysplastic syndrome and Onureg (azacitidine) is FDA approved for use in continued treatment of acute myeloid leukemia(FDA.gov).|
|Dubermatinib||TP-0903||AXL Inhibitor 28||Dubermatinib (TP-0903) is a selective Axl inhibitor that inhibits tumor cell survival (PMID: 22247788, PMID: 32460059, PMID: 31992541).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04518345||Phase Ib/II||Dubermatinib Azacitidine + Dubermatinib||TP-0903 for the Treatment of FLT3 Mutated Acute Myeloid Leukemia||Recruiting||USA||0|