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Therapy Name GSK3845097
Synonyms
Therapy Description

GSK3845097 are autologous T lymphocytes engineered to express a dominant negative TGF-beta and a T-cell receptor targeting NY-ESO-1, which may lead to cytotoxic T-cell-mediated killing of NY-ESO-1-overexpressing tumor cells (J Clin Oncol 39, no. 15_suppl, abstract TPS2661).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GSK3845097 GSK-3845097|GSK 3845097 GSK3845097 are autologous T lymphocytes engineered to express a dominant negative TGF-beta and a T-cell receptor targeting NY-ESO-1, which may lead to cytotoxic T-cell-mediated killing of NY-ESO-1-overexpressing tumor cells (J Clin Oncol 39, no. 15_suppl, abstract TPS2661).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04526509 Phase I Cyclophosphamide + Fludarabine GSK3901961 GSK3845097 Master Protocol to Assess Safety and Dose of First Time in Human Next Generation Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Advanced Solid Tumors Active, not recruiting USA | NLD | DEU | CAN | AUS 1


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