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Therapy Name DLYE5953A
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DLYE5953A RG 7841|RG-7841|RG7841 DLYE5953A is an antibody drug conjugate comprising of an anti-Ly6E monoclonal antibody linked to monomethyl auristatin E, with potential to inhibit tumor growth and proliferation (PMID: 32694157).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable DLYE5953A Phase I Actionable In a Phase I trial, DLYE5953A treatment resulted in an overall objective response rate of 12% (8/68, all partial responses), and stable disease in 54% (37/68) of patients with advanced solid tumors, including a cohort of breast cancer patients with a partial response in 10% (3/29) and a cohort of non-small cell lung cancer patients with a partial response in 20% (5/25) (PMID: 32694157; NCT02092792). 32694157
Unknown unknown lung non-small cell carcinoma not applicable DLYE5953A Case Reports/Case Series Actionable In a Phase I trial, a patient with non-small cell lung carcinoma expressing Ly6e (IHC 3+) who initially responded to prior treatments including chemotherapy regimens and Opdivo (nivolumab), but then progressed, achieved a partial response with a 46% decrease in tumor size after 2 cycles of DLYE5953A treatment, but treatment was discontinued after cycle 6 due to disease progression (PMID: 32694157; NCT02092792). 32694157
Unknown unknown triple-receptor negative breast cancer not applicable DLYE5953A Case Reports/Case Series Actionable In a Phase I trial, a patient with triple-receptor negative breast cancer expressing Ly6e (IHC 3+), who progressed on prior treatments, achieved stable disease as best response with a 14% decrease of the primary tumor after 2 cycles of DLYE5953A treatment, but treatment was discontinued after cycle 5 due to disease progression (PMID: 32694157; NCT02092792). 32694157

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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