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Therapy Name Defactinib + RO5126766
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Defactinib VS-6063|PF-04554878 FAK inhibitor 15 Defactinib (VS-6063) inhibits FAK, resulting in decreased downstream signaling, and potentially leading to reduced tumor cell proliferation and survival (PMID: 31739184).
RO5126766 Avutometinib|VS-6766|VS6766|VS 6766|CH5126766|CH-5126766|R-7304|RG-7304 MEK inhibitor (Pan) 26 MEK1 Inhibitor 26 MEK2 Inhibitor 24 RAF Inhibitor (Pan) 28 RO5126766 (VS-6766) is a RAF/MEK inhibitor, which potentially leads to decreased tumor cell growth and inhibition of tumor growth (PMID: 34288272).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04620330 Phase II Defactinib + RO5126766 RO5126766 A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer (RAMP202) Completed USA | ITA | FRA | ESP | DEU 0
NCT04625270 Phase II Defactinib + RO5126766 RO5126766 A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation (RAMP 201) Active, not recruiting USA | ITA | GBR | FRA | ESP | CAN | BEL 0
NCT05787561 Phase II Defactinib + RO5126766 A Study of VS-6766 and Defactinib in People With Mesonephric Gynecologic Cancer Recruiting USA 0
NCT06194929 Phase Ib/II Defactinib + Encorafenib + RO5126766 Defactinib + RO5126766 Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma (DETERMINE) Recruiting USA 0
NCT06007924 Phase II Defactinib + RO5126766 A Study of Avutometinib and Defactinib in People With Thyroid Cancer Recruiting USA 0
NCT05512208 Phase II Defactinib + RO5126766 A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib (DURAFAK) Recruiting USA 0
NCT06072781 Phase III Paclitaxel Pegylated liposomal doxorubicin Defactinib + RO5126766 Topotecan Anastrozole Letrozole A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer (RAMP 301) Recruiting USA | GBR | AUS 0
NCT06487221 Phase II Defactinib + RO5126766 Avutometinib and Defactinib in Diffuse Gastric Cancer Recruiting USA 0
NCT03875820 Phase I Defactinib + RO5126766 Phase I Trial of Defactinib and VS-6766. (FRAME) Active, not recruiting GBR 0
NCT04720417 Phase II Defactinib + RO5126766 Defactinib (VS-6063) Combined With VS-6766 in Patients With Metastatic Uveal Melanoma Active, not recruiting USA 0


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