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|Therapy Name||Entinostat + M7824 + NHS-IL12|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Entinostat||HDAC inhibitor SNDX-275|MS 275||HDAC Inhibitor 41||Entinostat (MS-275) inhibits HDAC activity, with selectivity towards HDAC1, 2, and 3, which results in increased histone acetylation, and potentially leads to decreased tumor cell proliferation and tumor growth (PMID: 19724929, PMID: 17383217, PMID: 32503469).|
|M7824||Bintrafusp alfa|MSB0011359C||Immune Checkpoint Inhibitor 141 PD-L1/PD-1 antibody 83 TGFBR2 Antibody 2||Bintrafusp alfa (M7824) is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).|
|NHS-IL12||M9241|M-9241||NHS-IL12 (M9241) is an immunocytokine composed of IL-12 linked to human tumor necrosis factor targeted IgG1, which may result in enhanced anti-tumor immune response (PMID: 24681847).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04708470||Phase Ib/II||Entinostat + M7824 + NHS-IL12||Phase I/II Trial of the Combination of Bintrafusp Alfa (M7824), Entinostat and NHS-IL12 (M9241) in Patients With Advanced Cancer||Recruiting||USA||0|