Therapy Detail

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Therapy Name PNT2002
Synonyms
Therapy Description

PNT2002 is a radioconjugate consisting of a PSMA-targeting ligand (PNT2002) attached to the radioisotope Lu 177, that binds to tumor cells expressing PSMA, potentially resulting in tumor cell death (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PNT2002 PNT-2002|PNT 2002|Lu-177-PNT2002|177Lu-PNT2002|[Lu-177]-PSMA-I and T PNT2002 is a radioconjugate consisting of a PSMA-targeting ligand (PNT2002) attached to the radioisotope Lu 177, that binds to tumor cells expressing PSMA, potentially resulting in tumor cell death (NCI Drug Dictionary).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05893381 Phase II PNT2002 Lu-PSMA and Stereotactic Radiotherapy Versus Radiotherapy Alone for Prostate Cancer (LUST) (LUST) Recruiting ITA 0
NCT06033001 Expanded access PNT2002 Expanded Access Treatment With [Lu-177]-PNT2002 for Adult Patients With Prostate-Specific Membrane Antigen (PSMA)-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC) Available USA 0
NCT05496959 Phase II PNT2002 177-Lutetium-PSMA Before Stereotactic Body Radiotherapy for the Treatment of Oligorecurrent Prostate Cancer, The LUNAR Study (LUNAR) Active, not recruiting USA 0
NCT04647526 Phase III Abiraterone + Dexamethasone Abiraterone + Prednisone Enzalutamide PNT2002 Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment (SPLASH) Active, not recruiting USA | NLD | GBR | FRA | CAN 1
NCT05230251 Phase II PNT2002 Radioligand fOr locAl raDiorecurrent proStaTe cancER (ROADSTER) Active, not recruiting CAN 0
NCT06322576 Phase II PNT2002 177Lu-PSMA (177Lu-PNT2002) in PSMA-Positive Adenoid Cystic Carcinoma Not yet recruiting USA 0


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