Therapy Detail

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Therapy Name Cetrelimab + TAR-200
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cetrelimab JNJ63723283|JNJ 63723283|JNJ-63723283 Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 115 Cetrelimab (JNJ-63723283) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28943093).
TAR-200 GemRIS|TAR 200 Chemotherapy - Antimetabolite 14 TAR-200 comprises gemcitabine delivered through an intravesical delivery system that results in gradual release of gemcitabine, which inhibits DNA synthesis and potentially leads to increased tumor cell apoptosis (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05714202 Phase III BCG solution Cetrelimab + TAR-200 TAR-200 A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (SunRISe-3) Recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 12
NCT04640623 Phase II Cetrelimab + TAR-200 TAR-200 A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guerin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy Recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 7
NCT04919512 Phase II Cetrelimab + TAR-200 Cetrelimab A Study of TAR-200 in Combination With Cetrelimab and Cetrelimab Alone in Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder (SunRISe-4) Recruiting USA | ITA | GBR | FRA | ESP | DEU | BEL 3
NCT04658862 Phase III Cisplatin Cetrelimab + TAR-200 Gemcitabine A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT | AUS 16


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