Therapy Detail

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Therapy Name NX-2127
Synonyms
Therapy Description

NX-2127 is a small molecule that induces degradation of BTK, which may lead to inhibition of the growth of malignant B-cells (PMID: 38301010).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NX-2127 NX 2127|NX2127 BTK inhibitor 36 NX-2127 is a small molecule that induces degradation of BTK, which may lead to inhibition of the growth of malignant B-cells (PMID: 38301010).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK C481S diffuse large B-cell lymphoma sensitive NX-2127 Preclinical - Cell line xenograft Actionable In a preclinical study, NX-2127 inhibited viability of a diffuse large B-cell lymphoma cell line expressing BTK C481S in culture (PMID: 38301010). 38301010
BTK V416L diffuse large B-cell lymphoma sensitive NX-2127 Preclinical - Cell culture Actionable In a preclinical study, NX-2127 inhibited viability of a diffuse large B-cell lymphoma cell line expressing BTK V416L in culture (PMID: 38301010). 38301010
BTK L528W diffuse large B-cell lymphoma sensitive NX-2127 Preclinical - Cell culture Actionable In a preclinical study, NX-2127 inhibited viability of a diffuse large B-cell lymphoma cell line expressing BTK L528W in culture (PMID: 38301010). 38301010
BTK T474I diffuse large B-cell lymphoma sensitive NX-2127 Preclinical - Cell culture Actionable In a preclinical study, NX-2127 inhibited viability of a diffuse large B-cell lymphoma cell line expressing BTK T474I in culture (PMID: 38301010). 38301010
BTK C481R BTK L528W chronic lymphocytic leukemia predicted - sensitive NX-2127 Case Reports/Case Series Actionable In a Phase I trial, NX-2127 treatment resulted in a partial response in a patient with chronic lymphocytic leukemia harboring BTK C481R and L528W, who had progressed on prior BTK inhibitors (PMID: 38301010; NCT04830137). 38301010

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04830137 Phase I NX-2127 A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies Active, not recruiting USA 0


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