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|Therapy Name||Ado-trastuzumab emtansine + TAEK-VAC-HerBy|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ado-trastuzumab emtansine||Kadcyla||T-DM1|trastuzumab emtansine||HER2 (ERBB2) Antibody 63 HER2 (ERBB2) Antibody-Drug Conjugate 24||Kadcyla (ado-trastuzumab emtansine) is an antibody-drug conjugate (ADC) comprised of the ERBB2 (HER2) monoclonal antibody, trastuzumab, and an anti-tubulin agent, DM1, which results in tumor cell cytotoxicity (PMID: 24887180). Kadcyla (ado-trastuzumab emtansine) is FDA approved for metastatic ERBB2 (HER2)-positive (overexpression or gene amplification) breast cancer patients who have previously received trastuzumab and/or taxane, and for the adjuvant treatment of patients with ERBB2 (HER2)-positive early breast cancer who have residual invasive disease after taxane and trastuzumab-based treatment (FDA.gov).|
|TAEK-VAC-HerBy||TAEK-VAC-HerBy Vaccine||HER2 (ERBB2) Vaccine 12||TAEK-VAC-HerBy is a cancer vaccine targeted against Erbb2 (Her2) receptor on tumor cells, and may lead to inhibition of cell proliferation, induction of a T-cell immune response, and tumor cell killing (NCI Thesaurus).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04246671||Phase Ib/II||TAEK-VAC-HerBy Pertuzumab + TAEK-VAC-HerBy + Trastuzumab Ado-trastuzumab emtansine + TAEK-VAC-HerBy TAEK-VAC-HerBy + Trastuzumab||TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer||Recruiting||USA||0|