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|Therapy Name||Basiliximab + Carmustine + Cytarabine + Etoposide + Filgrastim + Yttrium Y 90 Basiliximab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Basiliximab||Simulect||CHI-621|SDZ-CHI-621||Simulect (basiliximab) is an antibody that binds and inhibits IL-2, potentially resulting in reduced T-cell activation and decreased immune response (PMID: 16098072, PMID: 12476283).|
|Carmustine||Becenun||BCNU||Chemotherapy - Alkylating 16||Becenun (carmustine) is an antineoplastic alkylating agent, which cross-links DNA and disrupts the cell-cycle (NCI Drug Dictionary).|
|Cytarabine||Cytosar-U||Ara-C||Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309).|
|Etoposide||Vepesid||EPEG|Eposin|VP-16|VP-16-213||TOPO2 inhibitor 5||Vepesid (etoposide) binds to and inhibits DNA topoisomerase II, resulting in accumulated DNA damage, inhibition of replication, and cell death (NCI Drug Dictionary).|
|Filgrastim||Neupogen||G-CSF||Neupogen (filgrastim) is a recombinant analog of granulocyte colony-stimulating factor (G-CSF) isoform B, which binds and activates G-CSF receptors modulating neutrophilic granulocyte progenitor activity, production, and differentiation (NCI Drug Dictionary).|
|Yttrium Y 90 Basiliximab||90Y basiliximab||Yttrium Y 90 Basiliximab consists of an anti-IL-2 receptor antibody (basiliximab) conjugated to radioactive yttrium Y 90, which binds to IL-2R and prevents IL-2 binding, as well as delivering cytotoxic radiation to IL-2R expressing cells, thereby potentially decreasing T-cell activation and immune response (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04871607||Phase II||Basiliximab + Carmustine + Cytarabine + Etoposide + Filgrastim + Yttrium Y 90 Basiliximab||Yttrium-90 Labeled Anti-CD25 Monoclonal Antibody Combined With BEAM Chemotherapy Conditioning for the Treatment of Primary Refractory or Relapsed Hodgkin Lymphoma||Recruiting||USA||0|