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|Therapy Name||Voxtalisib + XL147|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Voxtalisib||XL765|XL-765|SAR245409|SAR-245409||mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40||Voxtalisib (XL765) inhibits both PI3K and mTOR kinases and results in inhibition of PI3K pathway signaling, thereby possibly leading to inhibition of cell proliferation, reduced tumor vascularization, and inhibition of tumor growth (PMID: 24634413, PMID: 31870556).|
|XL147||SAR245408|Pilaralisib|XL-147||PI3K Inhibitor (Pan) 40||Pilaralisib (XL147) is an inhibitor of all class I PI3Ks, thereby blocking activation of the PI3K signaling pathway and potentially resulting in antitumor activity including inhibition of cell proliferation, cell invasion, and tumor growth (PMID: 25637314, PMID: 29593099).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|