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|Therapy Name||Alectinib + SHP099|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Alectinib||Alecensa||CH5424802|RO5424802||ALK Inhibitor 29 RET Inhibitor 48||Alecensa (alectinib) is an inhibitor of RET and ALK, including ALK fusions and the gatekeeper mutation, L1196M (PMID: 21575866, PMID: 25349307). Alecensa (alectinib) is FDA-approved for use in patients with ALK-positive (rearrangements and fusions) non-small cell lung cancer (FDA.gov).|
|SHP099||SHP-099|SHP 099||SHP2 Inhibitor 19||SHP099 is an allosteric inhibitor of SHP2 that stabilizes SHP2 in its autoinhibited conformation, which reduces downstream signaling and potentially leads to decreased growth of receptor tyrosine kinase-driven tumors (PMID: 27362227, PMID: 31043123).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK||lung non-small cell carcinoma||sensitive||Alectinib + SHP099||Preclinical - Cell line xenograft||Actionable||In a preclinical study, the combination of Alecensa (alectinib) and SHP099 inhibited downstream signaling and synergistically inhibited proliferation in non-small cell lung cancer cell lines harboring EML4-ALK in culture, and resulted in increased suppression of tumor growth in cell line xenograft models compared to either agent alone (PMID: 34158345).||34158345|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|