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|Therapy Name||Carfilzomib + HDP-101|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Carfilzomib||Kyprolis||PR-171||Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov).|
|HDP-101||HDP101||TNFRSF17 Antibody 14||HDP-101 is an antibody-drug conjugate (ADC) comprising an antibody targeting the anti-B cell maturation antigen (BCMA) linked to a derivative of amanitin, which binds to BCMA-positive tumor cells, potentially leading to induction of apoptosis, tumor cell killing, and inhibition of tumor growth (PMID: 33298585).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|