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|Therapy Name||ERAS-007 + Osimertinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ERAS-007||ERAS007|ERAS 007||ERAS-007 is an inhibitor of ERK1/2 which potentially results in decreased phosphorylation of ERK targets and activation of the MAPK/ERK pathway, leading to reduced cell proliferation (NCI Drug Dictionary).|
|Osimertinib||Tagrisso||AZD9291||EGFR Inhibitor 3rd gen 21||Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EFGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EFGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04959981||Phase Ib/II||ERAS-007 + Osimertinib||A Study of ERAS-007 in Patients With Advanced Non-Small-Cell Lung Cancer (HERKULES-2)||Recruiting||USA||0|