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|Therapy Name||Avelumab + IDH1 R132H peptide vaccine|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Avelumab||Bavencio||MSB0010718C||Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 86||Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov).|
|IDH1 R132H peptide vaccine||IDH1 R132H peptide vaccine is a cancer vaccine comprising a peptide that includes the IDH1 R132H mutation, which may increase immune response against tumor cells harboring IDH1 R132H, resulting in decreased tumor growth (PMID: 25043048).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03893903||Phase I||Avelumab IDH1 R132H peptide vaccine Avelumab + IDH1 R132H peptide vaccine||AMPLIFYing NEOepitope-specific VACcine Responses in Progressive Diffuse Glioma (AMPLIFY-NEOVAC)||Recruiting||DEU||0|