Therapy Detail
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| Therapy Name | VSV-delta51 |
| Synonyms | |
| Therapy Description |
VSV-delta51 is an oncolytic vesicular stomatitis virus (VSV) with a deletion of methionine 51 in the M protein, which may induce a cytotoxic response in tumor cells and an antitumor immune response (PMID: 14585354, PMID: 33593882). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| VSV-delta51 | VSV(M Delta 51) | VSV-delta51 is an oncolytic vesicular stomatitis virus (VSV) with a deletion of methionine 51 in the M protein, which may induce a cytotoxic response in tumor cells and an antitumor immune response (PMID: 14585354, PMID: 33593882). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 dec exp | melanoma | predicted - sensitive | VSV-delta51 | Preclinical - Cell culture | Actionable | In a preclinical study, siRNA knockdown of JAK2 in a melanoma cell line resulted in increased sensitivity to treatment with an oncolytic virus, VSV-delta51, in culture (PMID: 33593882). | 33593882 |
| JAK2 loss | melanoma | sensitive | VSV-delta51 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with VSV-delta51 resulted in decreased cell viability in melanoma cell lines with a loss of JAK2 in culture, and resulted in an increased median survival in a syngeneic mouse model grafted with a CRISPR-mediated JAK2 knockout melanoma cell line (PMID: 33593882). | 33593882 |
| JAK2 LOH JAK2 inact mut | melanoma | predicted - sensitive | VSV-delta51 | Preclinical - Patient cell culture | Actionable | In a preclinical study, a melanoma patient-derived cell line harboring an inactivating JAK2 mutation and JAK2 loss of heterozygosity resulted in sensitivity to treatment with an oncolytic virus, VSV-delta51, in culture (PMID: 33593882). | 33593882 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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