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|Therapy Name||Avelumab + MRx0518|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Avelumab||Bavencio||MSB0010718C||Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 86||Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov).|
|MRx0518||MRx 0518|MRx-0518||Microbiome 5||MRx0518 is a strain of isolated gut microbiota that may have antitumor efficacy (Journal of Clinical Oncology 36, no. 15_suppl, PMID: 30692549).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05107427||Phase II||Avelumab + MRx0518||Study of MRx0518 and Avelumab in Patients With Urothelial Carcinoma (AVENU)||Recruiting||USA||0|