Therapy Detail

Therapy Name nab-paclitaxel + GSK1120212
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Nab-paclitaxel Abraxane ABI-007 Chemotherapy - Taxane 2 Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary).
Trametinib Mekinist GSK1120212 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Mekinist (trametinib) inhibits MEK 1 and 2, which potentially leads to reduced tumor cell proliferation (PMID: 27956260). Mekinist (trametinib) is FDA approved for melanoma patients harboring BRAF V600E or BRAF V600K mutations, and in combination with Tafinlar (dabrafinib) for BRAF V600E/K-mutant melanoma, BRAF V600E- mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT02300935 Phase I nab-paclitaxel + GSK1120212 Study of Trametinib and Nab-paclitaxel in Patients With Melanoma Withdrawn
NCT01376310 Phase II Docetaxel + Trametinib Erlotinib + Trametinib Trametinib Pemetrexed + GSK1120212 Carboplatin + GSK1120212 nab-paclitaxel + GSK1120212 Gemcitabine + GSK1120212 Everolimus + GSK1120212 GSK1120212 Rollover Study Terminated