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|Therapy Name||ERAS-007 + Osimertinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ERAS-007||ASN007|ASN-007|ASN 007|ERAS007|ERAS 007||ERK Inhibitor (pan) 18||ERAS-007 (ASN007) is a small molecule that inhibits ERK1/2, which may result in decreased tumor cell proliferation and reduced tumor growth (PMID: 34337566).|
|Osimertinib||Tagrisso||AZD9291||EGFR Inhibitor 3rd gen 24||Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04959981||Phase Ib/II||ERAS-007 + Osimertinib ERAS-601 + Sotorasib ERAS-007 + Sotorasib||A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC||Recruiting||USA||0|