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|Therapy Name||Dacomitinib + Gedatolisib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Dacomitinib||Vizimpro||PF-00299804|PF299804||EGFR Inhibitor 2nd gen 3 HER inhibitor (Pan) 5||Vizimpro (dacomitinib) is a second-generation EGFR inhibitor and pan-HER inhibitor that inhibits HER2 and multiple EGFR subtypes including EGFR T790M, resulting in decreased proliferation and increased apoptosis in EGFR-expressing and HER2-expressing tumor cells (PMID: 22761403, PMID: 18606718). Vizimpro (dacomitinib) is FDA approved for use in patients with metastatic non-small cell lung cancer with EGFR exon 19 deletion or L858R mutation as first-line treatment (FDA.gov).|
|Gedatolisib||PKI-587|PF-05212384|PF 05212384||mTOR Inhibitor 51 PI3K Inhibitor (Pan) 37||Gedatolisib (PF-05212384) is an ATP-competitive inhibitor that targets phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, and may result in antitumor activity, including inhibition of tumor growth and tumor regression (PMID: 21325073, PMID: 31822716).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT01920061||Phase I||Dacomitinib + Gedatolisib Cisplatin + Gedatolisib Docetaxel + Gedatolisib||A Study Of PF-05212384 In Combination With Other Anti-Tumor Agents and in Combination With Cisplatin in Patients With Triple Negative Breast Cancer in an Expansion Arm (TNBC)||Completed|