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|Therapy Name||Ceralasertib + Niraparib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ceralasertib||AZD6738|AZD-6738||ATR Inhibitor 13||Ceralasertib (AZD6738) is an inhibitor of ATR, which may enhance the sensitivity of chemotherapeutic agents, potentially resulting in tumor regression (PMID: 26517239, PMID: 31836456).|
|Niraparib||Zejula||MK4827||PARP Inhibitor (Pan) 25||Zejula (niraparib) binds and inhibits PARP, which may result in accumulation of DNA damage and apoptosis of tumor cells (PMID: 23810788). Zejula (niraparib) is FDA-approved as maintenance therapy in patients with recurrent or newly-diagnosed epithelial ovarian, fallopian tube, or primary peritoneal cancer in complete or partial response to platinum-based chemotherapy, and in ovarian, fallopian tube, or primary peritoneal cancer that received 3 or more chemotherapies and is homologous recombination deficient as indicated by either a deleterious or suspected deleterious BRCA mutation, or genomic instability and progressed 6 months or more after response to last platinum-based chemotherapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|IDH1 R132H||Advanced Solid Tumor||sensitive||Ceralasertib + Niraparib||Preclinical - Cell culture||Actionable||In a preclinical study, the combination of Zejula (niraparib) and Ceralasertib (AZD6738) resulted in a greater decrease in cell viability compared to Ceralasertib (AZD6738) alone in cells expressing IDH1 R132H in culture (PMID: 34027408).||34027408|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|