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|Therapy Name||Enzalutamide + NUV-868|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Enzalutamide||Xtandi||MDV3100|ASP9785||Hormone - Anti-androgens 47||Xtandi (enzalutamide) is a second-generation small molecule inhibitor of androgen receptor, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA-approved for use in patients with castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (FDA.gov).|
|NUV-868||NUV868|NUV 868||BET Inhibitor (Pan) 32||NUV-868 selectively binds to the BD2 domain of the BRD4 protein, leading to disruption of chromatin remodeling and decreased expression of oncogenes, potentially leading to growth inhibition of tumor cells (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05252390||Phase Ib/II||NUV-868 NUV-868 + Olaparib Enzalutamide + NUV-868||NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors||Recruiting||USA | AUS||0|