Therapy Detail
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| Therapy Name | Telisotuzumab vedotin |
| Synonyms | |
| Therapy Description |
Telisotuzumab vedotin (ABBV-399) is an antibody-drug conjugate comprising a MET-targeted antibody linked to MMAE, which delivers the cytotoxic agent to MET expressing tumor cells, resulting in cell death (PMID: 27573171, PMID: 32127466). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Telisotuzumab vedotin | ABBV-399|Teliso-V | MET Antibody 27 | Telisotuzumab vedotin (ABBV-399) is an antibody-drug conjugate comprising a MET-targeted antibody linked to MMAE, which delivers the cytotoxic agent to MET expressing tumor cells, resulting in cell death (PMID: 27573171, PMID: 32127466). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03574753 | Phase II | Telisotuzumab vedotin | Lung-MAP S1400K: c-MET Positive | Completed | USA | 0 |
| NCT02099058 | Phase I | Carboplatin + Telisotuzumab vedotin Erlotinib + Telisotuzumab vedotin Telisotuzumab vedotin Bevacizumab + Telisotuzumab vedotin Cetuximab + Telisotuzumab vedotin | A Phase 1/1b Study With ABBV-399, an Antibody Drug Conjugate, in Subjects With Advanced Solid Cancer Tumors | Active, not recruiting | USA | ITA | FRA | BEL | 5 |
| NCT03539536 | Phase II | Telisotuzumab vedotin | Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer | Active, not recruiting | USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS | 17 |
| NCT04830202 | Expanded access | Telisotuzumab vedotin | Expanded Access to Telisotuzumab Vedotin | Available | USA | DEU | AUS | 2 |
| NCT04928846 | Phase III | Telisotuzumab vedotin Docetaxel | A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC) | Recruiting | USA | ITA | GBR | FRA | ESP | DEU | BEL | AUT | AUS | 21 |
| NCT05513703 | Phase II | Telisotuzumab vedotin | A Study to Assess Disease Activity of Intravenously (IV) Infused Telisotuzumab Vedotin in Adult Participants With Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) | Recruiting | USA | ITA | FRA | DEU | AUS | 4 |
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