Therapy Detail

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Therapy Name Carboplatin + Paclitaxel Trevatide + trastuzumab and hyaluronidase-oysk injection
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Carboplatin Paraplatin CBDCA Chemotherapy - Platinum 7 Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary).
Paclitaxel Trevatide ANG1005|GRN1005 Chemotherapy - Taxane 3 Paclitaxel Trevatide (GRN1005) consists of paclitaxel bound to a peptide that binds LRP-1, which allows the drug-peptide conjugate to cross the blood-brain barrier and delivers paclitaxel to LRP-1 expressing tumor cells (PMID: 22203732, PMID: 23349317).
trastuzumab and hyaluronidase-oysk injection Herceptin Hylecta HER2 (ERBB2) Antibody 72 Herceptin Hylecta (trastuzumab and hyaluronidase-oysk injection) is an injectable formulation consists of Herceptin (trastuzumab) and hyaluronidase, which demonstrates anti-tumor activity against ERBB2 (HER2)-positive breast cancer (PMID: 28625777). Herceptin Hylecta (trastuzumab and hyaluronidase-oysk injection) is FDA-approved for use in patients with Erbb2 (Her2)-overexpressing and/or Erbb2 (Her2) amplified breast cancer (FDA.gov).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05256225 Phase II Carboplatin + Paclitaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Carboplatin + Paclitaxel Carboplatin + Paclitaxel Trevatide + trastuzumab and hyaluronidase-oysk injection Testing the Addition of Trastuzumab or Trastuzumab/Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma Recruiting USA 1


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