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Therapy Name Ezabenlimab + NK-92/5.28.z
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ezabenlimab BI754091|BI-754091|BI 754091 Immune Checkpoint Inhibitor 148 PD-L1/PD-1 antibody 117 Ezabenlimab (BI 754091) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (J Clin Oncol. 36, no. 5_suppl (February 2018) 212-212).
NK-92/5.28.z HER2.taNK|Anti-HER2-CAR-CD28zeta NK-92 Cells NK-92/5.28.z are NK-92 natural killer cell line-derived cells engineered to express a chimeric antigen receptor (CAR) that targets ERBB2 (HER2) and contains CD28 and the signaling domain from CD3zeta, which potentially results in tumor cell cytotoxicity and inhibition of tumor growth (PMID: 28879551, PMID: 25373520).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03383978 Phase I Ezabenlimab + NK-92/5.28.z Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma (CAR2BRAIN) Active, not recruiting DEU 0


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