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|Therapy Name||Trastuzumab + XL147|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Trastuzumab||Herceptin||Anti HER2||HER2 (ERBB2) Antibody 37||Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov).|
|XL147||SAR245408|Pilaralisib||PI3K Inhibitor (Pan) 37||Pilaralisib (XL147) is an inhibitor of all class I PI3Ks, thereby blocking activation of the PI3K signaling pathway and potentially resulting in antitumor activity including inhibition of cell proliferation, cell invasion, and tumor growth (PMID: 25637314).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ERBB2 T798M||breast cancer||sensitive||Trastuzumab + XL147||Preclinical||Actionable||In a preclinical study, breast cancer cells expressing ERBB2 (HER2) T798M were sensitive to the combination of Herceptin (trastuzumab) and XL147 (PMID: 23948973).||23948973|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|