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|Therapy Name||Brigatinib + Cetuximab + Icotinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Brigatinib||Alunbrig||AP26113||ALK Inhibitor 29 EGFR Inhibitor (Pan) 57 FLT3 Inhibitor 61 IGF-1R Inhibitor 17 ROS1 Inhibitor 19||Alunbrig (brigatinib) is a multi-kinase inhibitor with selected activity against ALK, ROS1 fusions, FLT3, IGF1R and mutant EGFR, potentially resulting in decreased tumor growth (PMID: 27780853). Alunbrig (brigatinib) is FDA approved for use in patients with ALK-positive metastatic non-small cell lung cancer (FDA.gov).|
|Cetuximab||Erbitux||IMC-C225||EGFR Antibody 43||Erbitux (cetuximab) is a monoclonal antibody directed against EGFR, which inhibits signal transduction and cell proliferation (PMID: 28695301). Erbitux (cetuximab) is FDA approved for use in head and neck squamous cell carcinoma and KRAS wild-type, EGFR positive colorectal cancer (FDA.gov).|
|Icotinib||BPI-2009|BPI-2009H|Conmana||EGFR Inhibitor 1st gen 3||Icotinib (BPI-2009) is a selective EGFR inhibitor that inhibits both wild-type and mutant forms of EGFR, which may result in decreased tumor cell proliferation (PMID: 22112293).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|