Therapy Detail

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Therapy Name Docetaxel + Gemcitabine
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Docetaxel Taxotere RP56976 Antimicrotubule Agent 14 Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558).
Gemcitabine Gemzar Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 Chemotherapy - Antimetabolite 14 Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03971474 Phase II Docetaxel + Gemcitabine + Pemetrexed Disodium Docetaxel + Ramucirumab Docetaxel + Gemcitabine Pembrolizumab + Ramucirumab Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial) Active, not recruiting USA 0
NCT02659020 Phase Ib/II Olaratumab Docetaxel + Gemcitabine A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma Completed USA | ITA | GBR | FRA | ESP | DEU | AUS 3
NCT01593748 Phase II Docetaxel + Gemcitabine Gemcitabine + Pazopanib A Treatment Trial Comparing Gemcitabine and Pazopanib Versus Gemcitabine and Docetaxel for Patients With Advanced Soft Tissue Sarcoma Completed USA 0
NCT02049905 Phase III Dacarbazine Doxorubicin Ifosfamide Pazopanib Aldoxorubicin Docetaxel + Gemcitabine Phase 3 Study to Treat Patients With Soft Tissue Sarcomas Completed USA | ITA | FRA | ESP | CAN | AUS 7
NCT02511132 Phase II FANG vaccine Docetaxel + Gemcitabine FANG vaccine + Irinotecan + Temozolomide A Two-part Phase IIb Trial of Vigil in Ewing's Sarcoma Completed USA 0
NCT04145700 Phase Ib/II Docetaxel + Gemcitabine + Ramucirumab Docetaxel + Gemcitabine CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma Terminated USA | ITA | GBR | FRA | ESP | DEU | BEL | AUS 2
NCT02045446 Phase II Bevacizumab + Erlotinib Docetaxel + Gemcitabine Maintenance Chemotherapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Chemotherapy for Stage IV Non-Small Cell Lung Cancer (NSCLC) Completed USA 0


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