Therapy Detail
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| Therapy Name | Glofitamab-gxbm + RO7227166 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Glofitamab-gxbm | Columvi | RO 7082859|RO-7082859|RO7082859 | CD20 Antibody 21 CD3 Antibody 91 | Columvi (glofitamab-gxbm) is a bispecific antibody that binds the tumor-associated antigen, MS4A1 (CD20), and CD3 on T-cells to stimulate T-cell killing of CD20-expressing tumor cells (PMID: 36507690). Columvi (glofitamab-gxbm) is FDA-approved for use in patients with relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified or large B-cell lymphoma (LBCL) arising from follicular lymphoma, after two or more lines of systemic therapy (FDA.gov). |
| RO7227166 | RO 7227166|RO-7227166|Ensomafusp Alfa|RG6076|RG-6076|RG 6076|Englumafusp Alfa | CD19 Antibody 20 TNFRSF9 Antibody 30 | RO7227166 is a bispecific antibody that targets both CD19 and TNFRSF9 (4-1BB), potentially resulting in enhanced anti-tumor immune response (Blood (2022) 140 (Supplement 1): 9461-9463). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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