Therapy Detail

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Therapy Name 1A46
Synonyms
Therapy Description

1A46 is a trispecific antibody that targets tumor-expressed CD19 and CD20, and T cell-expressed CD3, which potentially leads to an enhanced cytotoxic T-lymphocyte (CTL) response against tumor cells expressing CD19 and CD20 (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
1A46 CMG1A46|CMG 1A46|CMG-1A46 CD19 Antibody 20 CD20 Antibody 21 CD3 Antibody 96 1A46 is a trispecific antibody that targets tumor-expressed CD19 and CD20, and T cell-expressed CD3, which potentially leads to an enhanced cytotoxic T-lymphocyte (CTL) response against tumor cells expressing CD19 and CD20 (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05348889 Phase Ib/II 1A46 First-in-Human (FIH) Trial of 1A46 in Subjects With Advanced CD20 and/or CD19 Positive B-cell Hematologic Malignancies Recruiting USA 0


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