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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|SGI-1027||SGI 1027||DNMT inhibitor (Pan) 5||SGI-1027 binds and inhibits DNMT1, DNMT3A, and DNMT3B, which leads to decreased DNA methylation and may result the activation of silenced tumor suppressor genes (PMID: 19417133, PMID: 30344731).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||SGI-1027||Preclinical - Cell culture||Actionable||In a preclinical study, SGI-1027, inhibited DNA methylation and reactivated silenced tumor suppressor genes, and induced DNMT1 degradation in a variety of cancer cell lines in culture (PMID: 19417133).||19417133|
|Unknown unknown||hepatocellular carcinoma||not applicable||SGI-1027||Preclinical - Cell culture||Actionable||In a preclinical study, treatment with SGI-1027 reduced proliferation of a rat hepatoma cell line in culture in culture (PMID: 19417133).||19417133|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|