Therapy Detail

Therapy Name RO5520985
Synonym
Therapy Description

Vanucizumab (RO5520985) is a bispecific human antibody that binds to both Angiopoeitin-2 and VEGF-A, inhibiting tumor angiogenesis and metastasis in xenograft models (PMID: 24097868).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
RO5520985 Vanucizumab|Ang-2-VEGF-A CrossMab Vanucizumab (RO5520985) is a bispecific human antibody that binds to both Angiopoeitin-2 and VEGF-A, inhibiting tumor angiogenesis and metastasis in xenograft models (PMID: 24097868).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable RO5520985 Phase I Actionable In a Phase I trial, Vanucizumab (RO5520985) treatment in advanced solid tumor patients resulted in some preliminary antitumor activity including a partial response in two patients and stable disease in nineteen patients (PMID: 29217526; NCT01688206). 29217526
Unknown unknown ovarian cancer not applicable RO5520985 Phase I Actionable In a Phase I clinical trial, Vanucizumab (RO5520985) treatment resulted in partial response in 29% (12/41) and stable disease in 54% of (22/41) platinum (Pt)- resistant/refractory epithelial ovarian cancer patients (J Clin Oncol 33, 2015 (suppl; abstr 5549)). detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT02141295 Phase II Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin RO5520985 Bevacizumab + Fluorouracil + Leucovorin Fluorouracil + Leucovorin + RO5520985 Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab A Study Comparing the Efficacy and Safety of RO5520985 and FOLFOX With Bevacizumab and FOLFOX in Patients With Untreated Metastatic Colorectal Cancer (McCAVE) Completed