Therapy Detail

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Therapy Name rAD-p53
Synonyms
Therapy Description

Gendicine (rAD-p53) is a replication-defective adenoviral vector encoding wild-type TP53, which induces tumor cells to produce wild-type Tp53 and potentially induce apoptosis. Gendicine may also stimulate a cytotoxic T-lymphocyte immune response against tumor cells, and activate natural killer cells (PMID: 29338444, PMID: 32013587, PMID: 30618300).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
rAD-p53 Gendicine|Genkaxin p53 Gene Therapy 4 Gendicine (rAD-p53) is a replication-defective adenoviral vector encoding wild-type TP53, which induces tumor cells to produce wild-type Tp53 and potentially induce apoptosis. Gendicine may also stimulate a cytotoxic T-lymphocyte immune response against tumor cells, and activate natural killer cells (PMID: 29338444, PMID: 32013587, PMID: 30618300).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01574729 Phase II rAD-p53 Surgery Combined With rAd-p53 Gene in Treatment Advanced Non-small-cell Carcinoma Unknown status 1


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