Therapy Detail

Therapy Name Valproic Acid + Mitomycin C
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Mitomycin C Mitozytrex Chemotherapy - Alkylating 14 Mitomycin C is an antibiotic alkylating agent, which cross-links DNA to prevent DNA synthesis (NCI Drug Dictionary).
Valproic acid Depakene Depacon HDAC Inhibitor 34 Valproic acid inhibits HDAC activity, potentially resulting in decreased angiogenesis, increased tumor cell differentiation, and reduced tumor growth (PMID: 11742974, PMID: 14978230). Valproic acid is FDA-approved for use in treating seizures (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colon cancer not applicable Valproic Acid + Mitomycin C Preclinical Actionable In a preclinical study, Depakene (valproic acid), in combination with Mitozytrex (mitomycin C), inhibited cell viability of colon cancer cells isolated from patients (PMID: 17024798). 17024798
Clinical Trial Phase Therapies Title Recruitment Status