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|Therapy Name||Clofarabine + Edelfosine + Gemcitabine|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Clofarabine||Clolar||Clofarex||Clolar (clofarabine) is a purine nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase, preventing DNA synthesis and repair, and induces apoptosis by inhibiting mitochondrial function (NCI Drug Dictionary).|
|Edelfosine||ET-18-OCH3||Edelfosine is an ether lipid that modulates cell membrane properties, inhibits PKC, and inhibits the PI3K-AKT/PKB pathway, activating the pro-apoptotic stress-activated protein kinase SAPK/JNK pathways, thereby inducing apoptosis selectively in tumor cells (PMID: 9257915).|
|Gemcitabine||Gemzar||Difluorodeoxycytidine Hydrochlorothiazide|LY-188011||Chemotherapy - Antimetabolite 11||Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|