Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|GANT61||GANT-61||GLI1/2 inhibitor 6||GANT61 is a small molecule inhibitor of hedgehog signaling that acts on GLI1 and GLI2 to block transcription and has demonstrated antitumor activity in xenograft models (PMID: 17494766, PMID: 32677544, PMID: 32504326).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||colon cancer||not applicable||GANT61||Preclinical||Actionable||In a preclinical study, treatment with the GLI1/GLI2 inhibitor, GANT61, resulted in cytotoxicity in colon cancer cell lines (PMID: 21135115).||21135115|
|Unknown unknown||neuroblastoma||not applicable||GANT61||Preclinical - Cell line xenograft||Actionable||In a preclinical study, GANT61 induced apoptosis and decreased growth of neuroblastoma cells in culture, and inhibited tumor growth in neuroblastoma cell line xenograft models (PMID: 22949014).||22949014|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|