Therapy Detail
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| Therapy Name | Bardoxolone methyl |
| Synonyms | |
| Therapy Description |
Bardoxolone methyl (CDDO-Me) is a derivative of a synthetic triterpenoid, 2-cyano-3,12-dioxooleana- 1,9-dien-28-oic acid (CDDO), which targets KEAP1, leading to the activation of NRF2. CDDO-Me also binds to IKK? and inhibits NF-?B activation. CDDO-Me is developed for the treatment of inflammation and cancer (PMID: 25364233) |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bardoxolone methyl | CDDO-Me|RTA 402 | Bardoxolone methyl (CDDO-Me) is a derivative of a synthetic triterpenoid, 2-cyano-3,12-dioxooleana- 1,9-dien-28-oic acid (CDDO), which targets KEAP1, leading to the activation of NRF2, and also binds to IKKB and inhibits NF-KB activation. CDDO-Me is developed for the treatment of inflammation and cancer (PMID: 25364233, PMID: 32370011) |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| Unknown unknown | Advanced Solid Tumor | not applicable | Bardoxolone methyl | Phase I | Actionable | In a Phase I trial, Bardoxolone methyl (CDDO-Me) was well tolerated by patients with advanced solid tumors, with a complete tumor response observed in a mantle cell lymphoma patient (PMID: 25364233). | 25364233 |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|
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