Therapy Detail

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Therapy Name Ado-trastuzumab emtansine + Neratinib
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ado-trastuzumab emtansine Kadcyla T-DM1|trastuzumab emtansine HER2 (ERBB2) Antibody 50 Kadcyla (ado-trastuzumab emtansine) is an antibody drug conjugate combined of the ERBB2 (HER2) monoclonal antibody, trastuzumab, and an anti-tubulin agent, DM1, which results in tumor cell cytotoxicity (PMID: 24887180). Kadcyla (ado-trastuzumab emtansine) is FDA approved for metastatic ERBB2 (HER2)-positive (overexpression or gene amplification) breast cancer patients who have previously received trastuzumab and/or taxane, and for the adjuvant treatment of patients with ERBB2 (HER2)-positive early breast cancer who have residual invasive disease after taxane and trastuzumab-based treatment (FDA.gov).
Neratinib Nerlynx HKI-272|PB272 HER2 Inhibitor 26 Nerlynx (neratinib) inhibits the ERBB2 (HER2) receptor as well as EGFR, resulting in decreased proliferation of HER2 and EGFR expressing tumor cells (PMID: 15173008). Nerlynx (neratinib) is FDA approved for use in patients with early stage ERBB2 (HER2)-positive breast cancer following Herceptin (trastuzumab)-based therapy, and in combination with Xeloda (capecitabine) in patients with advanced/metastatic ERBB2 (HER2)-positive breast cancer who have received two or more anti-ERBB2 (HER2) regimens (FDA.gov).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 amp Her2-receptor positive breast cancer predicted - sensitive Ado-trastuzumab emtansine + Neratinib Case Reports/Case Series Actionable In a Phase II trial, a patient with ERBB2 (HER2) amplified breast cancer who had progressed on Kadcyla (ado-trastuzumab emtansine) was switched to combination therapy with Kadcyla (ado-trastuzumab emtansine) and Nerlynx (neratinib), which led to a partial response (38%) after 6 weeks, and remained on combination treatment for an additional 12 weeks at which intracranial progression was observed (PMID: 32213539; NCT01494662). 32213539
ERBB2 S310F ERBB2 amp lung cancer predicted - sensitive Ado-trastuzumab emtansine + Neratinib Preclinical - Pdx Actionable In a preclinical study, combination treatment with Kadcyla (ado-trastuzumab emtansine) and Nerlynx (neratinib) in a patient-derived xenograft (PDX) model of lung cancer harboring ERBB2 (HER2) amplification and ERBB2 (HER2) S310F resulted in greater inhibition of tumor growth than either agent alone (PMID: 32213539). 32213539

Filtering

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02236000 Phase Ib/II Ado-trastuzumab emtansine + Neratinib A Dose-Escalation Study Evaluating the Combination of Trastuzumab Emtansine (T-DM1) With Neratinib in Women With Metastatic HER2-Positive Breast Cancer Active, not recruiting USA 0


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