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Therapy Name JIB-04
Synonyms
Therapy Description

JIB-04 is a selective small molecule inhibitor of the histone demethylases KDM4A, KDM4B, KDM4C, KDM4D, KDM4E, KDM5A, and KDM6B, demonstrating specific activity in cancer cells not seen in matched normal controls. Jib-04 treatment induced transcriptional changes reducing cellular proliferation and promoting apoptosis of cancer cells (PMID: 23792809).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
JIB-04 JIB-04 is a selective small molecule inhibitor of the histone demethylases KDM4A, KDM4B, KDM4C, KDM4D, KDM4E, KDM5A, and KDM6B, demonstrating specific activity in cancer cells not seen in matched normal controls, and also induced transcriptional changes reducing cellular proliferation and promoting apoptosis of cancer cells (PMID: 23792809, PMID: 32581546).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable JIB-04 Preclinical Actionable In a preclinical study, JIB-04, a pan Jumonji histone demethylase inhibitor, reduced cell proliferation, and induced apoptosis in multiple cancer cell types while reducing tumor burden and increasing survival in mouse xenograft models (PMID: 23792809). 23792809

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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