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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ME-344||ME-344 is an isoflavone derivative which interferes with mitochondrial energy production in tumor cells resulting in caspase-independent cell death (PMID: 25411085, PMID: 31597662).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||ME-344||Phase I||Actionable||In a Phase I trial, ME-344 demonstrated preliminary tolerability and efficacy in patients with advanced solid tumors (PMID: 25411085).||25411085|
|Unknown unknown||Her2-receptor negative breast cancer||not applicable||ME-344||Phase 0||Actionable||In a Phase 0/I trial, addition of ME-344 to Avastin (bevacizumab) treatment resulted in a 23.4% decrease of Ki67 in treatment-naive patients with early-stage Erbb2 (Her2)-negative breast cancer, compared to a 186% increase in the placebo arm (PMID: 31597662; NCT02806817).||31597662|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|