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Therapy Name Canertinib
Synonyms
Therapy Description

Canertinib (CI-1033) is a pan-ERBB inhibitor that inhibits EGFR, ERBB2 (HER2), ERBB3 (HER3), and ERBB4 (HER4) signaling, which may result in decreased tumor growth (PMID: 11706399, PMID: 17342332).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Canertinib CI-1033 EGFR Inhibitor (Pan) 46 HER inhibitor (Pan) 5 Canertinib (CI-1033) is a pan-ERBB inhibitor that inhibits EGFR, ERBB2 (HER2), ERBB3 (HER3), and ERBB4 (HER4) signaling, which may result in decreased tumor growth (PMID: 11706399, PMID: 17342332, PMID: 30425998).

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  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 L1157R cancer sensitive Canertinib Preclinical - Cell culture Actionable In a preclinical study, Canertinib (CI-1033) inhibited growth of transformed cells expressing ERBB2 (HER2) L1157R in culture (PMID: 32366937). 32366937
ERBB2 G776_V777insYVMA Advanced Solid Tumor sensitive Canertinib Preclinical Actionable In a preclinical study, Canertinib inhibited Erbb2 (Her2) phosphorylation and cell growth in transformed human cell lines expressing ERBB2 (HER2) G776_V777insYVMA (PMID: 16843263). 16843263
ERBB2 R188C cancer sensitive Canertinib Preclinical - Cell culture Actionable In a preclinical study, Canertinib (CI-1033) inhibited growth of transformed cells expressing ERBB2 (HER2) R188C in culture (PMID: 32366937). 32366937
ERBB2 P489L cancer sensitive Canertinib Preclinical - Cell culture Actionable In a preclinical study, Canertinib (CI-1033) inhibited growth of transformed cells expressing ERBB2 (HER2) P489L in culture (PMID: 32366937). 32366937

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status


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