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|Therapy Name||Sorafenib + YIV-906|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Sorafenib||Nexavar||BAY 43-9006||CSF1R Inhibitor 24 FLT3 Inhibitor 55 KIT Inhibitor 51 PDGFR-beta Inhibitor 13 RAF Inhibitor (Pan) 16 RET Inhibitor 39 VEGFR2 Inhibitor 35||Nexavar (sorafenib) is a multikinase inhibitor with activity against several kinases, including RAF kinases, VEGFR2, VEGFR3, PDGFR-beta, KIT, FLT3, RET, and CSF1R, potentially resulting in decreased tumor growth (PMID: 18445656, PMID: 15466206, PMID: 21517818). Nexavar (sorafenib) is approved for metastatic differentiated thyroid carcinoma, hepatocellular carcinoma, and renal cell carcinoma (FDA.gov).|
|YIV-906||PHY906|KD018||YIV-906 (KD018) is an herbal formulation whose mechanism of action is unclear, but which results in inhibition of CYP3A4, MMP, NF-KB, beta-glucuronidase, and the NK-1 receptor, as well as modulation of certain cytokines, macrophages and lymphocytes (PMID: 25819872, PMID: 31617551).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT01666756||Phase I||Sorafenib + YIV-906||Chinese Herbal Formulation PHY906 and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer||Active, not recruiting|