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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|BC21||CTNNB1 Inhibitor 27||BC21 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling, which can prevent cell proliferation and induce apoptosis (PMID: 22224445).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|CTNNB1 mutant||colorectal cancer||sensitive||BC21||Preclinical||Actionable||In a preclinical study, BC21 inhibited growth and viability of a colorectal cancer cell line with a CTNNB1 mutation and increased beta-catenin expression in culture (PMID: 22224445).||22224445|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|