Therapy Detail

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Therapy Name MRT-92
Synonyms
Therapy Description

MRT-92 binds to and inhibits Smoothened (SMO), resulting in decreased Hedgehog (Hh) pathway signaling and reduced tumor cell proliferation (PMID: 25636740).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MRT-92 SMO Inhibitor 16 MRT-92 binds to and inhibits Smoothened (SMO), resulting in decreased Hedgehog (Hh) pathway signaling and reduced tumor cell proliferation (PMID: 25636740).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMO E518K Advanced Solid Tumor predicted - resistant MRT-92 Preclinical Actionable In a preclinical study, transformed human cells expressing SMO E518K displayed reduced binding to MRT-92 (PMID: 25636740). 25636740
SMO T466F Advanced Solid Tumor predicted - resistant MRT-92 Preclinical Actionable In a preclinical study, transformed human cells expressing SMO T466F displayed reduced binding to MRT-92 (PMID: 25636740). 25636740
SMO M525G Advanced Solid Tumor predicted - resistant MRT-92 Preclinical Actionable In a preclinical study, transformed human cells expressing SMO M525G displayed reduced binding to MRT-92 (PMID: 25636740). 25636740
SMO Y394A Advanced Solid Tumor predicted - resistant MRT-92 Preclinical Actionable In a preclinical study, transformed human cells expressing SMO Y394A displayed reduced binding to MRT-92 (PMID: 25636740). 25636740
SMO V329F Advanced Solid Tumor predicted - resistant MRT-92 Preclinical Actionable In a preclinical study, transformed human cells expressing SMO V329F displayed reduced binding to MRT-92 (PMID: 25636740). 25636740
SMO D384A Advanced Solid Tumor predicted - resistant MRT-92 Preclinical Actionable In a preclinical study, transformed human cells expressing SMO D384A displayed reduced binding to MRT-92 (PMID: 25636740). 25636740
SMO L325F Advanced Solid Tumor predicted - resistant MRT-92 Preclinical Actionable In a preclinical study, transformed human cells expressing SMO L325F displayed reduced binding to MRT-92 (PMID: 25636740). 25636740
SMO R400A Advanced Solid Tumor predicted - sensitive MRT-92 Preclinical Actionable In a preclincal, transformed human cells expressing SMO R400A displayed reduced binding to MRT-92 (PMID: 25636740). 25636740

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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