Therapy Detail

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Therapy Name Varlilumab
Synonyms
Therapy Description

Varlilumab is an activating monoclonal antibody that binds to CD27 and potentially increases antibody-dependent cellular cytotoxicity towards CD27 positive tumor cells (PMID: 22589397).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Varlilumab CDX-1127|CDX127 Varlilumab (CDX-1127) is an activating monoclonal antibody that binds to CD27 and potentially increases antibody-dependent cellular cytotoxicity towards CD27 positive tumor cells (PMID: 22589397, PMID: 32380537).

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Hodgkin's lymphoma not applicable Varlilumab Phase I Actionable In a Phase I trial, Varlilumab (CDX-1127) was well tolerated in heavily pretreated Hodgkin's lymphoma patients (n=11), and resulted in one patient with stable disease and one patient who achieved a complete response and remained in remission over 33 months following onset of treatment (PMID: 32380537; NCT01460134). 32380537
Unknown unknown follicular lymphoma not applicable Varlilumab Case Reports/Case Series Actionable In a Phase I trial, Varlilumab (CDX-1127) was well tolerated in heavily pretreated patients with follicular lymphoma, and resulted in stable disease in three patients (3/5), with disease control lasting between 4.5 and 14 months, including one patient who experienced 5.6 months of stable disease and a 36% reduction of measurable disease (PMID: 32380537; NCT01460134). 32380537
Unknown unknown non-Hodgkin lymphoma not applicable Varlilumab Phase I Actionable In a Phase I trial, Varlilumab (CDX-1127) was well tolerated in heavily pretreated patients with B-cell or T-cell non-Hodgkin lymphoma, and resulted in three B-cell patients (3/18, all follicular lymphomas) with stable disease and one T-cell patient (1/5) with stable disease (PMID: 32380537; NCT01460134). 32380537

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Clinical Trial Phase Therapies Title Recruitment Status
NCT02924038 Phase I IMA950 + Poly ICLC Varlilumab A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG) Recruiting
NCT02284971 Phase I Varlilumab Pilot Study of SBRT and CDX-1127 in Prostate Cancer (Prostate-04) Terminated
NCT02270372 Phase I Varlilumab ONT-10 Study of ONT-10 and Varlilumab to Treat Advanced Ovarian or Breast Cancer Completed


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